Abstract This study describes the experimental methodology to obtain hydroxy-functional methacrylate-based gel beads in millimeter-sized under production conditions by addition of the frozen pre-gel solution into the silicon oil as continuous phase using tetraethyleneglycol dimethacrylate (TEGDMA) as the crosslinking agent. Weakly basic cationic comonomer N,N -dimethylaminoethyl methacrylate (DMAEMA) was included into the polymerization procedure for the production of uniform polycationic moities exhibiting a drastic response against pH. The aim of this work is to determine the actual conditions for optimum bead production and to provide poly(hydroxypropyl methacrylate-co- N,N -dimethylaminoethyl methacrylate)-based P(HPMA-co-DMAEMA) gel beads with simple tools for the physical characterization. By the proposed experimental method, the physico-chemical properties of P(HPMA-co-DMAEMA) gel beads can be controlled by adjusting the pH, temperature of solution, ionic strength as well as the structure of the gel network. From the uniaxial compression tests, the swelling dependent stress–strain characteristics of resulting gel beads was evaluated. The obtained results were consistent with Hertzian elasticity, and were analyzed in terms of the compression modulus of the bead samples. It was found that force acting on the gel beads is the power-law function of the deformation F ≈ Δ D 1.48 which is very close to the theoretical exponent 1.5 predicted by the Hertz equation. The water absorption capacities of P(HPMA-co-DMAEMA) gel beads with basic functional groups were repeatedly measured to obtain the optimal preparation conditions according to the variations of the bead diameters. Its maximal water absorption capacity appeared as 48 times among from 2.3 mm to 11.0 mm of swollen bead diameters. The swelling equilibria in various aqueous solutions were used to estimate the physico-chemical parameters as a function of gel bead size and swelling equilibrium capacity by correlating with the Flory-Rehner theory.

中文翻译：

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调整基于聚（羟基官能甲基丙烯酸酯）带阳离子电荷的凝胶珠的物理化学性质和弹性：通过冷冻液滴结合疏水性和机械耐久性

摘要 本研究描述了以四乙二醇二甲基丙烯酸酯 (TEGDMA) 作为交联剂，通过将冷冻的预凝胶溶液添加到作为连续相的硅油中，在生产条件下获得毫米级羟基官能甲基丙烯酸酯基凝胶珠的实验方法。 . 弱碱性阳离子共聚单体 N,N-二甲基氨基乙基甲基丙烯酸酯 (DMAEMA) 被包括在聚合过程中，用于生产对 pH 表现出剧烈响应的均匀聚阳离子部分。这项工作的目的是确定最佳珠生产的实际条件，并提供基于聚（甲基丙烯酸羟丙酯-co-N,N-二甲氨基乙基甲基丙烯酸酯）的 P(HPMA-co-DMAEMA) 凝胶珠，其具有简单的物理工具。表征。通过提出的实验方法，P(HPMA-co-DMAEMA)凝胶珠的理化性质可以通过调节pH值、溶液温度、离子强度以及凝胶网络结构来控制。从单轴压缩试验中，评估了所得凝胶珠的溶胀依赖应力-应变特性。所得结果与赫兹弹性一致，并根据珠粒样品的压缩模量进行分析。发现作用在凝胶珠上的力是变形 F ≈ Δ D 1.48 的幂律函数，非常接近赫兹方程预测的理论指数 1.5。重复测量具有碱性官能团的P(HPMA-co-DMAEMA)凝胶珠的吸水能力，以根据珠直径的变化获得最佳制备条件。其最大吸水能力在 2.3 毫米至 11.0 毫米的溶胀珠直径之间出现 48 倍。通过与 Flory-Rehner 理论相关联，使用各种水溶液中的溶胀平衡来估计作为凝胶珠尺寸和溶胀平衡容量的函数的物理化学参数。