Abstract Monodisperse, tunable thermosensitive copolymer N , N -diethylacrylamide (DEA) and N , N -dimethylacrylamide (DMA) nanogels with up to 40 wt% of highly hydrophilic comonomer DMA have been prepared. The effect of synthesis parameters on the formulation of the nanogels as a function of monomer composition, surfactant concentration, initiator concentration, and crosslinker concentration are studied systematically. It is found that monodisperse DEA/DMA nanogels with a high composition of the hydrophilic DMA monomer are only synthesized at a very low initiator concentration, while an increasing initiator concentration lead to the formation of precipitates soon after polymerization. Brilliant colloidal crystals are assembled from the above monodisperse polyDEA and DEA/DMA nanogel by using the high temperature evaporation method. Both the monomer DMA composition and polymer concentration affect the structural colors (or λ max ). Furthermore, these hydrophilic nanogels are found to be resistant to protein adsorption, setting the way for promising applications to biosensor/biotechnology, such as drug delivery, and electrophoretic DNA sequencing.

中文翻译：

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热敏 DEA/DMA 共聚物纳米凝胶：低引发剂诱导合成和结构彩色胶体阵列的光学特性

摘要 已经制备了具有高达 40 wt% 的高亲水共聚单体 DMA 的单分散、可调热敏共聚物 N , N - 二乙基丙烯酰胺 (DEA) 和 N , N - 二甲基丙烯酰胺 (DMA) 纳米凝胶。系统地研究了合成参数对纳米凝胶配方的影响，作为单体组成、表面活性剂浓度、引发剂浓度和交联剂浓度的函数。发现具有高亲水性 DMA 单体组成的单分散 DEA/DMA 纳米凝胶仅在非常低的引发剂浓度下合成，而增加引发剂浓度会导致聚合后很快形成沉淀。将上述单分散聚DEA和DEA/DMA纳米凝胶采用高温蒸发方法组装成晶莹剔透的胶体晶体。单体 DMA 组成和聚合物浓度都会影响结构颜色（或 λ max ）。此外，发现这些亲水性纳米凝胶对蛋白质吸附具有抵抗力，为生物传感器/生物技术的有前景的应用奠定了基础，例如药物递送和电泳 DNA 测序。