An efficient and concise one‐pot protocol for the oxidative cross‐dehydrogenative coupling reaction of pyrazine N‐oxides and 1,3‐azole derivatives has been developed. Commercially available and inexpensive 1,3‐azoles were used as the coupling partners. Various biheteroaryl compounds were obtained in up to 67 % yields. This methodology provides a convinent way to construct the pyrazine–thiazole biheteroaryl moieties. Thermogravimetric analysis indicated that the fracture temperature of one of the biheteroaryl compounds was about 237 °C.

中文翻译：

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碱促进的氧化交叉脱氢偶联反应合成吡嗪-噻唑双杂芳基化合物

已开发出一种高效简明的一锅法用于吡嗪N-氧化物和1,3-唑衍生物的氧化交叉脱氢偶联反应。使用市售和廉价的1,3-唑类作为偶联伙伴。以高达67％的产率获得了各种双杂芳基化合物。该方法学提供了构建吡嗪-噻唑双杂芳基部分的简便方法。热重分析表明，一种双杂芳基化合物的断裂温度约为237℃。