Cu(TFA)2‐Catalyzed Picolinamido‐Directed C(sp2)−H Cyanation of Naphthalenes by Using Benzoyl Cyanide as a Cyano Source,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cu(TFA)2‐Catalyzed Picolinamido‐Directed C(sp2)−H Cyanation of Naphthalenes by Using Benzoyl Cyanide as a Cyano Source
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-08-31 , DOI: 10.1002/ajoc.201700418
He Song _{1,

2} , Xiaochong Liu _{1,

2} , Chenglong Wang _{1,

2} , Jingyi Qiao _{1,

2} , Wenyi Chu _{1,

2} , Zhizhong Sun _{1,

2}

Affiliation

A protocol for the Cu(TFA)₂‐catalyzed (TFA=trifluoroacetic acid) picolinamido‐directed C8−H cyanation of naphthalene derivatives with benzoyl cyanide as the cyano source has been developed. A series of 8‐cyano‐1‐(picolinamido)naphthalene derivatives were efficiently obtained in moderate to good yields by using this method. We prepared a total of 22 products, 10 of which have not previously been reported. Benzoyl cyanide was originally employed for the C(sp²)−H cyanation of arenes. The picolinamide moiety served a critical role as the directing group in this cyanation reaction of naphthalenes.

中文翻译：

Cu（TFA）2-催化苯甲酰氰化物为氰源的萘类的吡咯并氨基指示的C（sp2）-H氰化反应

已开发出一种以铜（TFA）₂催化（TFA =三氟乙酸）吡啶衍生物指导的萘衍生物以苯甲酰氰为氰基氰化C8-H氰化的方案。使用此方法可以有效地以中等到良好的产率获得一系列8-氰基-1-（吡啶并氨基）萘衍生物。我们总共准备了22种产品，其中10种以前没有报道过。苯甲酰氰最初用于芳烃的C（sp ²）-H氰化。吡啶甲酰胺部分在萘的氰化反应中起着指导基团的作用。

更新日期：2017-08-31

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11