A Formal Total Synthesis of (+)‐Frondosin A,Asian Journal of Organic Chemistry

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A Formal Total Synthesis of (+)‐Frondosin A
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-08-29 , DOI: 10.1002/ajoc.201700367
Kuktae Kwon ₁ , Jin Su Ham ₁ , Hyoun Young Kim ₁ , Vasu Sampath ₁ , Hee-Yoon Lee ₁

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An enantio‐ and stereoselective formal total synthesis of (+)‐frondosin A was accomplished through an oxidopyrylium‐ion‐mediated [5+2] cycloaddition reaction. The cycloaddition reaction provided not only an efficient way of constructing the frondosin skeleton but also facial discrimination through an ether bridge for complete control of relative stereochemistry of the substituents in frondosin A.

中文翻译：

（+）-Frondosin A的正式全合成

（+）-frondosin A的对映体和立体选择性正式全合成反应是通过氧化吡啶鎓离子介导的[5 + 2]环加成反应完成的。环加成反应不仅提供了构建frondosin骨架的有效方法，而且还提供了通过醚桥进行面部识别的方法，以完全控制frondosin A中取代基的相对立体化学。

更新日期：2017-08-29

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