Voltammetric Determination of Captopril on a Glassy Carbon Electrode Modified with Copper Metal-Organic Framework,Electroanalysis

当前位置： X-MOL 学术 › Electroanalysis › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Voltammetric Determination of Captopril on a Glassy Carbon Electrode Modified with Copper Metal-Organic Framework
Electroanalysis ( IF 2.7 ) Pub Date : 2017-09-04 , DOI: 10.1002/elan.201700384
Wellyton Silva Vasconcelos ₁ , Gilvaldo Gentil da Silva ₁ , Severino Alves Junior ₁ , Janaína Versiani dos Anjos ₁ , Madalena Carneiro da Cunha Areias ₁

Affiliation

We report in this work, a new method for the determination of captopril by differential pulse voltammetry using a glassy carbon electrode modified with a copper metal-organic framework (H-Kust-1 or Cu3(BTC)2 or Cu-BTC), immobilized on the surface by a copolymer of acrylamide and sodium acrylate. This compound is detected by the formation of a copper(II)-captopril complex that is observed in an oxidation potential at ca. +0.28 V vs. Ag/AgCl. A linear dynamic range is obtained for a captopril concentration of 0.5 μM to 7.0 μM and the voltammetric response is highly reproducible within 3.52 % error. The sensitivity of 9.71±0.37 nA μM−1 and the limit of detection of 0.20±0.01 μM make this methodology highly applicable for practical applications. The determination of captopril in a commercial pharmaceutical sample showed a recovery of 93.3 %.

中文翻译：

铜金属-有机骨架修饰玻碳电极上卡托普利的伏安法测定

我们在这项工作中报告了一种通过差分脉冲伏安法测定卡托普利的新方法，该方法使用固定化的铜金属有机骨架（H-Kust-1 或 Cu3(BTC)2 或 Cu-BTC）修饰的玻碳电极表面由丙烯酰胺和丙烯酸钠的共聚物制成。该化合物通过形成铜 (II)-卡托普利络合物来检测，该络合物在约 20 ℃的氧化电位中观察到。+0.28 V vs. Ag/AgCl。卡托普利浓度为 0.5 μM 至 7.0 μM 时获得线性动态范围，伏安响应在 3.52% 误差内具有高度重现性。9.71±0.37 nA μM-1 的灵敏度和 0.20±0.01 μM 的检测限使该方法非常适用于实际应用。商业药物样品中卡托普利的测定表明回收率为 93.3%。

更新日期：2017-09-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11