Electrochemical Detection of Hemoglobin: A Review,Electroanalysis

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Electrochemical Detection of Hemoglobin: A Review
Electroanalysis ( IF 2.7 ) Pub Date : 2017-07-12 , DOI: 10.1002/elan.201700308
Khalil Khadim Hussain ₁ , Jong-Min Moon ₁ , Deog-Su Park ₂ , Yoon-Bo Shim ₁

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Hemoglobin (Hb) is a tetrameric hemoprotein that is located in red blood cells (RBCs) and is responsible for O2 transport in the circulatory system. Conventionally, Hb assay is a specific and sensitive indicator for the diagnosis of anemia and other related diseases. To date, various methods have been used for the analysis of Hb, and of these, electrochemical method is the simplest and reliable technique. Therefore, several approaches have been reported for the quantification of Hb, including the direct electron transfer (DET) with or without a mediator onto the electrode surface, molecular imprinted polymer (MIPs), and immunoreaction. To realize the direct electrochemistry of Hb, the modification of the electrode surface either with a mediator or catalyst to promote the redox process, which can be applied for the sensitive and selective detection of Hb. This review contains a comprehensive introduction to electrochemical Hb detection methods using modified electrode surfaces. Finally, the review gives a brief insight into the electrochemical sensing platform developed for the analysis of other type of globins such as, myoglobin and glycated hemoglobin. The objectives of this review are to summarize various electrochemical detection methods for Hb and to facilitate future development of new sensing platforms for the medical and healthcare applications.

中文翻译：

血红蛋白的电化学检测：综述

血红蛋白 (Hb) 是一种四聚体血红蛋白，位于红细胞 (RBC) 中，负责循环系统中的 O2 运输。传统上，Hb 测定是诊断贫血和其他相关疾病的特异性和敏感指标。迄今为止，已使用多种方法来分析 Hb，其中电化学方法是最简单可靠的技术。因此，已经报道了几种定量 Hb 的方法，包括在电极表面有或没有介质的直接电子转移 (DET)、分子印迹聚合物 (MIP) 和免疫反应。为了实现 Hb 的直接电化学，用介体或催化剂修饰电极表面以促进氧化还原过程，可用于 Hb 的灵敏和选择性检测。本综述全面介绍了使用改性电极表面的电化学 Hb 检测方法。最后，该评论简要介绍了为分析其他类型的珠蛋白（如肌红蛋白和糖化血红蛋白）而开发的电化学传感平台。本综述的目的是总结 Hb 的各种电化学检测方法，并促进未来用于医疗和保健应用的新型传感平台的开发。肌红蛋白和糖化血红蛋白。本综述的目的是总结 Hb 的各种电化学检测方法，并促进未来用于医疗和保健应用的新型传感平台的开发。肌红蛋白和糖化血红蛋白。本综述的目的是总结 Hb 的各种电化学检测方法，并促进未来用于医疗和保健应用的新型传感平台的开发。

更新日期：2017-07-12

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