High Density Glycopolymers Functionalized Perylene Diimide Nanoparticles for Tumor-Targeted Photoacoustic Imaging and Enhanced Photothermal Therapy,Biomacromolecules

当前位置： X-MOL 学术 › Biomacromolecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

High Density Glycopolymers Functionalized Perylene Diimide Nanoparticles for Tumor-Targeted Photoacoustic Imaging and Enhanced Photothermal Therapy
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1021/acs.biomac.7b01029
Pengfei Sun ₁ , Pengcheng Yuan ₁ , Gaina Wang ₁ , Weixing Deng ₁ , Sichao Tian ₁ , Chao Wang ₁ , Xiaomei Lu ₂ , Wei Huang ₂ , Quli Fan ₁

Affiliation

Near-infrared (NIR) absorbing nanoagents with functions of photoacoustic imaging (PAI) and photothermal therapy (PTT) have received great attention for cancer therapy. However, endowing them with multifunctions, especially targeting ability, for enhancing in vivo PAI/PTT generally suffers from the problems of synthetic complexity and low surface density of function groups. We herein report high density glycopolymers coated perylenediimide nanoparticles (PLAC–PDI NPs), self-assembled by poly(lactose)-modified perylenediimide (PLAC–PDI), as tumor-targeted PAI/PTT nanoagents. Atom transfer radical polymerization and click reaction were used in sequence to prepare PLAC–PDI, which can accurately control the content of poly(lactose) (PLAC) in PLAC–PDI and endow PLAC–PDI NPs with high density PLAC surface. The high density PLAC surface provided NPs with long-time colloidal stability, outstanding stability in serum and light, and specific targeting ability to cancer cells and tumors. Meanwhile, PLAC–PDI NPs also presented high photothermal conversion efficiency of 42% by virtue of strong π–π interactions among perylenediimide molecules. In living mice, PAI experiments revealed that PLAC–PDI NPs exhibited effective targeting ability and enhanced PTT efficacy to HepG2 tumor compared with control groups, lactose blocking, and ASGP-R negative tumor groups. Overall, our work provids new insights for designing glycopolymers-based therapeutic nanoagents for efficient tumor imaging and antitumor therapy.

中文翻译：

高密度糖聚合物官能化的Di二酰亚胺纳米粒子用于肿瘤靶向的光声成像和增强的光热疗法

具有光声成像（PAI）和光热疗法（PTT）功能的近红外（NIR）吸收纳米剂已在癌症疗法中引起了广泛关注。然而，赋予它们增强体内PAI / PTT的多功能性，尤其是靶向能力，通常会遇到合成复杂性和功能基团的低表面密度的问题。我们在此报告了高密度糖聚合物包覆的per二酰亚胺纳米粒子（PLAC-PDI NPs），由聚（乳糖）改性的ylene二酰亚胺（PLAC-PDI）自组装，作为靶向肿瘤的PAI / PTT纳米剂。依次使用原子转移自由基聚合和点击反应制备PLAC-PDI，它可以精确控制PLAC-PDI中的聚乳糖（PLAC）的含量，并赋予PLAC-PDI NPs高密度的PLAC表面。高密度的PLAC表面为NP提供了长期的胶体稳定性，出色的血清和光稳定性以及对癌细胞和肿瘤的特异性靶向能力。同时，由于per二酰亚胺分子之间的强π-π相互作用，PLAC-PDI NPs还具有42％的高光热转换效率。在活体小鼠中，PAI实验表明，与对照组，乳糖阻断剂和ASGP-R阴性肿瘤组相比，PLAC-PDI NP对HepG2肿瘤表现出有效的靶向能力并增强了PTT功效。总体而言，我们的工作为设计基于糖聚合物的治疗性纳米剂提供了新的见解，从而可以有效地进行肿瘤成像和抗肿瘤治疗。由于per二酰亚胺分子之间存在很强的π-π相互作用，因此PLAC-PDI NPs还具有42％的高光热转化效率。在活体小鼠中，PAI实验表明，与对照组，乳糖阻断剂和ASGP-R阴性肿瘤组相比，PLAC-PDI NP对HepG2肿瘤表现出有效的靶向能力并增强了PTT功效。总体而言，我们的工作为设计基于糖聚合物的治疗性纳米剂提供了新的见解，从而可以有效地进行肿瘤成像和抗肿瘤治疗。由于per二酰亚胺分子之间存在很强的π-π相互作用，因此PLAC-PDI NPs还具有42％的高光热转化效率。在活体小鼠中，PAI实验表明，与对照组，乳糖阻断剂和ASGP-R阴性肿瘤组相比，PLAC-PDI NP对HepG2肿瘤表现出有效的靶向能力并增强了PTT功效。总体而言，我们的工作为设计基于糖聚合物的治疗性纳米剂提供了新的见解，从而可以有效地进行肿瘤成像和抗肿瘤治疗。和ASGP-R阴性肿瘤组。总体而言，我们的工作为设计基于糖聚合物的治疗性纳米剂提供了新的见解，从而可以有效地进行肿瘤成像和抗肿瘤治疗。和ASGP-R阴性肿瘤组。总体而言，我们的工作为设计基于糖聚合物的治疗性纳米剂提供了新的见解，从而可以有效地进行肿瘤成像和抗肿瘤治疗。

更新日期：2017-09-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11