Access to Some C5-Cyclised 2-Pyrones and 2-Pyridones via Direct Arylation; Retention of Chloride as a Synthetic Handle,European Journal of Organic Chemistry

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Access to Some C5-Cyclised 2-Pyrones and 2-Pyridones via Direct Arylation; Retention of Chloride as a Synthetic Handle
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-13 05:06:53 , DOI: 10.1002/ejoc.201700980
Aisling M. Prendergast ₁ , Leticia M. Pardo ₁ , Ian J. S. Fairlamb ₂ , Gerard P. McGlacken ₁

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A direct arylation protocol was developed for the intramolecular coupling of 2-pyrones and 2-pyridones, allowing access to a previously unavailable class of products. A C–Cl bond was retained at C-3 during the direct arylation process allowing further derivatisation (demonstrated by Suzuki–Miyaura coupling) at C-3.

中文翻译：

通过直接芳基化反应获得一些C5环化的2-吡喃酮和2-吡啶酮；保留氯化物作为合成手柄

开发了一种直接芳基化方案，用于2-吡喃酮和2-吡啶酮的分子内偶联，从而可以使用以前无法获得的一类产品。在直接芳基化过程中，AC–Cl键保留在C-3上，从而允许在C-3处进一步衍生化（由Suzuki–Miyaura偶联证明）。

更新日期：2017-09-13

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