Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications,Journal of Materials Chemistry B

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Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-08-10 00:00:00 , DOI: 10.1039/c7tb01588g
Dan Ma _{1,

2,

3,

4,

5} , Jingwen Chen _{6,

7,

8,

9,

10} , Yu Luo _{1,

2,

3,

4,

5} , Han Wang _{6,

7,

8,

9,

10} , Xiangyang Shi _{1,

2,

3,

4,

5}

Affiliation

We report a convenient strategy to prepare ultrasmall Fe₃O₄ nanoparticles (NPs) coated with zwitterion L-cysteine (Cys) for enhanced T₁-weighted magnetic resonance (MR) imaging applications. The formed Fe₃O₄–PEG–Cys NPs possess antifouling properties, good r₁ relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.

中文翻译：

两性离子涂层超小氧化铁纳米粒子，用于增强的T ₁加权磁共振成像应用

我们报告了一种方便的策略来制备涂有两性离子L-半胱氨酸（Cys）的超小型Fe ₃ O ₄纳米颗粒（NPs），以增强T ₁加权磁共振（MR）成像应用。形成的Fe ₃ O ₄ -PEG-Cys NPs具有防污性能，良好的r ₁弛豫性，优异的细胞相容性和血液相容性，可以用作增强血池和肿瘤MR成像的造影剂。

更新日期：2017-09-13

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