Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization,Organic Chemistry Frontiers

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Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-04 00:00:00 , DOI: 10.1039/c7qo00517b
Wei Zhang _{1,

2,

3,

4} , Wenlong Yu _{1,

2,

3,

4} , Qiangqiang Yan _{1,

2,

3,

4} , Zhanxiang Liu _{1,

2,

3,

4} , Yuhong Zhang _{1,

2,

3,

4,

5}

Affiliation

A novel method for the synthesis of multisubstituted oxazoles by palladium-catalyzed oxidative cyclization of N-acyl enamides has been developed. The reaction employs readily available iodobenzenes and enamides as the starting materials under mild reaction conditions and provides a reliable way to achieve versatile substituted oxazole derivatives.

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