Communication is essential for all domains of life. Bacteria use a plethora of small molecules to sense and orchestrate intra- and interspecies communication. Within this review, we will discuss different groups of signalling molecules, including autoinducers, virulence factors and morphogenic substances. On selected examples, we will shortly discuss their ecological roles and biosynthetic proposals. The major part of this review will focus on a systematic overview of the different synthetic methods applied towards the synthesis of signalling molecules and derivatives thereof. The described examples highlight the importance of organic synthetic method development and diversity-oriented total syntheses for structure verification, structure–function analysis and target identification.

中文翻译：

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微生物信号分子的全合成及功能分析

交流对于生活的所有领域都是必不可少的。细菌使用大量小分子来感知和协调种内和种间的交流。在这篇综述中，我们将讨论不同种类的信号分子，包括自诱导剂，毒力因子和形态发生物质。在选定的例子中，我们将简短地讨论它们的生态作用和生物合成建议。这篇综述的主要内容将集中于对合成信号分子及其衍生物的不同合成方法的系统概述。所描述的例子突显了有机合成方法开发和面向多样性的总合成对于结构验证，结构功能分析和目标识别的重要性。