Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus, Pyrenochaetopsis sp. RK10-F058, by screening for structurally unique metabolites using LC/MS analysis. Their structures were determined on the basis of NMR and mass spectrometric measurements. The absolute structures were confirmed by a combination of chemical methods including chemical degradation, a modified Mosher's method and Marfey's method, and comparison of the experimental electronic CD (ECD) spectrum with calculated one. Both compounds had a cyclopentanone-fused decaline skeleton and an N-methylated amino acid moiety derived from a serine. They showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.The Journal of Antibiotics advance online publication, 13 September 2017; doi:10.1038/ja.2017.103.

中文翻译：

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Wakodecalines A 和 B，从真菌 Pyrenochaetopsis sp. 中分离出的新十氢代谢物。 RK10-F058。


从真菌 Pyrenochaetopsis sp. 中分离出两种新的十氢萘代谢物 wakodecalines A 和 B。 RK10-F058，通过使用 LC/MS 分析筛选结构独特的代谢物。它们的结构是根据核磁共振和质谱测量确定的。通过化学降解、改进的 Mosher 法和 Marfey 法等化学方法的组合，以及实验电子 CD (ECD) 谱与计算谱的比较，确认了绝对结构。两种化合物均具有环戊酮稠合十氢骨架和源自丝氨酸的 N-甲基化氨基酸部分。它们对恶性疟原虫 3D7 菌株表现出中等程度的抗疟活性。《抗生素杂志》在线出版，2017 年 9 月 13 日； doi：10.1038/ja.2017.103。