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Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial.
The Lancet ( IF 98.4 ) Pub Date : 2017-Nov-18 , DOI: 10.1016/s0140-6736(17)32365-6 Daniel P Petrylak , Ronald de Wit , Kim N Chi , Alexandra Drakaki , Cora N Sternberg , Hiroyuki Nishiyama , Daniel Castellano , Syed Hussain , Aude Fléchon , Aristotelis Bamias , Evan Y Yu , Michiel S van der Heijden , Nobuaki Matsubara , Boris Alekseev , Andrea Necchi , Lajos Géczi , Yen-Chuan Ou , Hasan Senol Coskun , Wen-Pin Su , Miriam Hegemann , Ivor J Percent , Jae-Lyun Lee , Marcello Tucci , Andrey Semenov , Fredrik Laestadius , Avivit Peer , Giampaolo Tortora , Sufia Safina , Xavier Garcia del Muro , Alejo Rodriguez-Vida , Irfan Cicin , Hakan Harputluoglu , Ryan C Widau , Astra M Liepa , Richard A Walgren , Oday Hamid , Annamaria H Zimmermann , Katherine M Bell-McGuinn , Thomas Powles , Suet-Lai Shirley Wong , Thean Hsiang Tan , Elizabeth Jane Hovey , Timothy Dudley Clay , Siobhan Su Wan Ng , Annemie Rutten , Jean-Pascal Machiels , Herlinde Dumez , Susanna Yee-Shan Cheng , Kim Nguyen Chi , Cristiano Ferrario , Lisa Sengeloev , Niels Viggo Jensen , Constance Thibault , Brigitte Laguerre , Fredrik Laestadius , Florence Joly , Aude Flechon , Stéphane Culine , Catherine Becht , Günter Niegisch , Michael Stöckle , Marc-Oliver Grimm , Georgios Gakis , Wolfgang Schultze-Seemann , Haralambos Kalofonos , Dimitrios Mavroudis , Christos Papandreou , Vasilis Karavasilis , Aristotelis Bamias , Janos Révész , Lajos Geczi , Eli Rosenbaum , Raya Leibowitz-Amit , Daniel Kejzman , Avivit Peer , David Sarid , Giorgio Vittorio Scagliotti , Cora N Sternberg , Giampaolo Tortora , Sergio Bracarda , Andrea Necchi , Francesco Massari , Takahiro Osawa , Naoto Miyajima , Nobuo Shinohara , Fumimasa Fukuta , Chikara Ohyama , Wataru Obara , Shinichi Yamashita , Yoshihiko Tomita , Koji Kawai , Satoshi Fukasawa , Nobuaki Matsubara , Masafumi Oyama , Junji Yonese , Masayoshi Nagata , Motohide Uemura , Kazuo Nishimura , Mutsushi Kawakita , Hiroyuki Tsunemori , Katsuyoshi Hashine , Junichi Inokuchi , Akira Yokomizo , Satoshi Nagamori , Jae-Lyun Lee , Hyo Jin Lee , Se Hoon Park , Sun Young Rha , Yu Jung Kim , Yun-Gyoo Lee , Leticia Vazquez Cortés , Claudia Lorena Urzua Flores , Reinoud J B Blaisse , Michiel S van der Heijden , Ronald de Wit , Fransiscus L G Erdkamp , Maureen J B Aarts , Joanna Wojcik-Tomaszewska , Piotr Tomczak , Bozena Sikora-Kupis , Michael Schenker , Alina Amalia Herzal , Anghel Adrian Udrea , Petr Karlov , Sufia Z Safina , Boris Alekseev , Andrey Semenov , Roman Fomkin , Enrique Grande Pulido , F Xavier García Del Muro , Juan Ignacio Delgado Mignorance , Daniel Castellano Gauna , Alejo Rodríguez-Vida , Yu-Li Su , Yen-Chuan Ou , Chien-Liang Lin , Wen-Pin Su , Chia-Chi Lin , Su-Peng Yeh , Irfan Çiçin , Hakan Harputluoglu , Mustafa Erman , Hasan Senol Coskun , Yuksel Urun , Yurii Golovko , Igor Bondarenko , Ivan Sinielnikov , Thomas Powles , Simon Crabb , Isabel Syndikus , Robert Huddart , Santhanam Sundar , Simon Chowdhury , Naveed Sarwar , Alexandra Drakaki , Thomas Flaig , Chong Xian Pan , Daniel Petrylak , James Schwarz , Ivor Percent , Jennifer Cultrera , John Hainsworth , Benjamin Herms , William Lawler , Thomas Lowe , Scott Tagawa , Jeanny Aragon-Ching , Ulka Vaishampayan
The Lancet ( IF 98.4 ) Pub Date : 2017-Nov-18 , DOI: 10.1016/s0140-6736(17)32365-6 Daniel P Petrylak , Ronald de Wit , Kim N Chi , Alexandra Drakaki , Cora N Sternberg , Hiroyuki Nishiyama , Daniel Castellano , Syed Hussain , Aude Fléchon , Aristotelis Bamias , Evan Y Yu , Michiel S van der Heijden , Nobuaki Matsubara , Boris Alekseev , Andrea Necchi , Lajos Géczi , Yen-Chuan Ou , Hasan Senol Coskun , Wen-Pin Su , Miriam Hegemann , Ivor J Percent , Jae-Lyun Lee , Marcello Tucci , Andrey Semenov , Fredrik Laestadius , Avivit Peer , Giampaolo Tortora , Sufia Safina , Xavier Garcia del Muro , Alejo Rodriguez-Vida , Irfan Cicin , Hakan Harputluoglu , Ryan C Widau , Astra M Liepa , Richard A Walgren , Oday Hamid , Annamaria H Zimmermann , Katherine M Bell-McGuinn , Thomas Powles , Suet-Lai Shirley Wong , Thean Hsiang Tan , Elizabeth Jane Hovey , Timothy Dudley Clay , Siobhan Su Wan Ng , Annemie Rutten , Jean-Pascal Machiels , Herlinde Dumez , Susanna Yee-Shan Cheng , Kim Nguyen Chi , Cristiano Ferrario , Lisa Sengeloev , Niels Viggo Jensen , Constance Thibault , Brigitte Laguerre , Fredrik Laestadius , Florence Joly , Aude Flechon , Stéphane Culine , Catherine Becht , Günter Niegisch , Michael Stöckle , Marc-Oliver Grimm , Georgios Gakis , Wolfgang Schultze-Seemann , Haralambos Kalofonos , Dimitrios Mavroudis , Christos Papandreou , Vasilis Karavasilis , Aristotelis Bamias , Janos Révész , Lajos Geczi , Eli Rosenbaum , Raya Leibowitz-Amit , Daniel Kejzman , Avivit Peer , David Sarid , Giorgio Vittorio Scagliotti , Cora N Sternberg , Giampaolo Tortora , Sergio Bracarda , Andrea Necchi , Francesco Massari , Takahiro Osawa , Naoto Miyajima , Nobuo Shinohara , Fumimasa Fukuta , Chikara Ohyama , Wataru Obara , Shinichi Yamashita , Yoshihiko Tomita , Koji Kawai , Satoshi Fukasawa , Nobuaki Matsubara , Masafumi Oyama , Junji Yonese , Masayoshi Nagata , Motohide Uemura , Kazuo Nishimura , Mutsushi Kawakita , Hiroyuki Tsunemori , Katsuyoshi Hashine , Junichi Inokuchi , Akira Yokomizo , Satoshi Nagamori , Jae-Lyun Lee , Hyo Jin Lee , Se Hoon Park , Sun Young Rha , Yu Jung Kim , Yun-Gyoo Lee , Leticia Vazquez Cortés , Claudia Lorena Urzua Flores , Reinoud J B Blaisse , Michiel S van der Heijden , Ronald de Wit , Fransiscus L G Erdkamp , Maureen J B Aarts , Joanna Wojcik-Tomaszewska , Piotr Tomczak , Bozena Sikora-Kupis , Michael Schenker , Alina Amalia Herzal , Anghel Adrian Udrea , Petr Karlov , Sufia Z Safina , Boris Alekseev , Andrey Semenov , Roman Fomkin , Enrique Grande Pulido , F Xavier García Del Muro , Juan Ignacio Delgado Mignorance , Daniel Castellano Gauna , Alejo Rodríguez-Vida , Yu-Li Su , Yen-Chuan Ou , Chien-Liang Lin , Wen-Pin Su , Chia-Chi Lin , Su-Peng Yeh , Irfan Çiçin , Hakan Harputluoglu , Mustafa Erman , Hasan Senol Coskun , Yuksel Urun , Yurii Golovko , Igor Bondarenko , Ivan Sinielnikov , Thomas Powles , Simon Crabb , Isabel Syndikus , Robert Huddart , Santhanam Sundar , Simon Chowdhury , Naveed Sarwar , Alexandra Drakaki , Thomas Flaig , Chong Xian Pan , Daniel Petrylak , James Schwarz , Ivor Percent , Jennifer Cultrera , John Hainsworth , Benjamin Herms , William Lawler , Thomas Lowe , Scott Tagawa , Jeanny Aragon-Ching , Ulka Vaishampayan
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Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population.
中文翻译：
Ramucirumab 加多西他赛与安慰剂加多西他赛治疗铂类治疗后局部晚期或转移性尿路上皮癌患者的比较 (RANGE)：一项随机、双盲 3 期试验。
对于铂类难治性晚期或转移性尿路上皮癌患者来说，很少有具有独特作用机制的治疗方法。我们评估了多西紫杉醇加雷莫芦单抗（一种人 IgG1 VEGFR-2 拮抗剂）或安慰剂治疗该患者群体的疗效和安全性。
更新日期：2017-09-13
中文翻译：
Ramucirumab 加多西他赛与安慰剂加多西他赛治疗铂类治疗后局部晚期或转移性尿路上皮癌患者的比较 (RANGE)：一项随机、双盲 3 期试验。
对于铂类难治性晚期或转移性尿路上皮癌患者来说，很少有具有独特作用机制的治疗方法。我们评估了多西紫杉醇加雷莫芦单抗（一种人 IgG1 VEGFR-2 拮抗剂）或安慰剂治疗该患者群体的疗效和安全性。
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