Nickel-Catalyzed Synthesis of Stereochemically Defined Enamides via Bi- and Tricomponent Coupling Reaction,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nickel-Catalyzed Synthesis of Stereochemically Defined Enamides via Bi- and Tricomponent Coupling Reaction
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1021/acs.orglett.7b02166
Y. Liu ₁ , A. De Nisi ₁ , A. Cerveri ₁ , M. Monari ₁ , M. Bandini ₁

Affiliation

The stereoselective synthesis of (E)-trisubstituted tertiary enamides is documented via site-selective Ni-catalyzed β-arylation of allenamides with boronic acids in high yields (up to 89%). The nucleophilic character of the “organo-Ni” intermediates is further exploited to implement a one-pot tricomponent procedure involving the final allylation of aldehydes (yields up to 93%). Mechanistic insights and efficiency on a gram scale process were also documented.

中文翻译：

镍催化的双组分和三组分偶联反应合成立体化学定义的酰胺

（E）-三取代叔烯酰胺的立体选择性合成是通过高选择性（最高89％）的烯丙基酰胺与硼酸的位点选择性Ni催化的β-芳基化进行记录的。进一步利用“有机镍”中间体的亲核特性来实施一锅三组分方法，该方法涉及醛的最终烯丙基化（收率高达93％）。还记录了克级过程的机械原理和效率。

更新日期：2017-09-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11