Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects on the excitability of hippocampal neurons and networks. Crucially, these stress mediators and their actions exhibit unique spatiotemporal profiles, generating a complex combinatorial output with time- and space-dependent effects on hippocampal network excitability and seizure generation.

中文翻译：

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压力和癫痫：空间、时间和海马回路

压力是癫痫患者癫痫发作的主要诱因。承受压力会导致整个大脑释放多种压力介质，包括海马体，这是一个对压力敏感且容易癫痫发作的区域。压力介质与其各自的受体相互作用，对海马神经元和网络的兴奋性产生不同的影响。至关重要的是，这些压力介质及其作用表现出独特的时空特征，产生复杂的组合输出，对海马网络的兴奋性和癫痫发作具有时间和空间依赖性影响。