Just over 20 years ago, no treatments were available for multiple sclerosis, a disease characterised by two overlapping processes of nervous system injury: inflammatory destruction of myelin and neurodegeneration of grey and white matter.¹ Disease-modifying drugs, particularly the new oral medications, have changed the prognosis of multiple sclerosis, contributing to increased periods of disease stability and greater potential for rehabilitative therapies to reduce impairment.² In The Lancet Neurology, Robert Motl and colleagues³ argue that exercise can be a beneficial rehabilitation strategy for people with multiple sclerosis, but that three limitations obstruct translation of exercise research into practice: the quality and scope of the evidence, the need for improved understanding of the mechanisms underlying the beneficial effects of exercise, and the need for a framework and toolkit for knowledge translation.

中文翻译：

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多发性硬化症康复的新时代：中风的教训

就在20年前，还没有针对多发性硬化症的治疗方法，多发性硬化症的特征是神经系统损伤的两个重叠过程：髓磷脂的炎性破坏和灰质和白质的神经变性。¹疾病缓解药物，尤其是新的口服药物，已经改变了多发性硬化症的预后，导致疾病稳定期增加，并且有更大的潜力进行康复治疗以减少损伤。²在柳叶刀神经病学，罗伯特Motl和同事³ 认为运动可能是对多发性硬化症患者有益的康复策略，但存在以下三个局限性限制了运动研究向实践的转化：证据的质量和范围，对运动有益作用的潜在机制的更好理解，以及对知识翻译的框架和工具包的需求。