Amphiphilic conjugated polymer was designed and utilized as nanocarriers without further general encapsulation using PEGylated materials for photothermal therapy (PTT) and chemotherapy. These nanocarriers have maximum absorption in ideal phototherapeutic window between 800 and 850 nm and excellent photothermal conversion efficiency of 76% at 808 nm. It provides the simultaneous therapy of chemotherapy and PTT with the monitoring of photoacoustic imaging. After combined therapy via tail vein injection, complete remission and no recurrence of tumors can be observed over a course of 20 days, indicating these amphiphilic NPs has great potential for NIR photoacoustic imaging-guided photothermal and chemo combined therapy.

中文翻译：

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两亲近红外共轭聚合物，用于光热和化学联合疗法

两亲共轭聚合物被设计并用作纳米载体，而无需使用聚乙二醇化材料进行光热疗法（PTT）和化学疗法的进一步一般封装。这些纳米载体在800至850 nm的理想光疗窗口中具有最大吸收，并且在808 nm处具有76％的出色光热转换效率。它提供了化学疗法和PTT的同步治疗以及对光声成像的监控。通过尾静脉注射进行联合治疗后，在20天的疗程中可观察到完全缓解且未见肿瘤复发，这表明这些两亲性NP在NIR光声成像引导下的光热和化学联合治疗中具有巨大潜力。