Catalytic C–H amination at its limits: challenges and solutions,Organic Chemistry Frontiers

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Catalytic C–H amination at its limits: challenges and solutions
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1039/c7qo00547d
Damien Hazelard _{1,

2,

3,

4,

5} , Pierre-Antoine Nocquet _{1,

2,

3,

4,

5} , Philippe Compain _{1,

2,

3,

4,

5}

Affiliation

Catalytic C–H amination reactions enable direct functionalization of non-activated C(sp³)–H bonds with high levels of regio-, chemo- and stereoselectivity. As a powerful tool to unlock the potential of inert C–H bonds, C–H amination chemistry has been applied to the preparation of synthetically challenging targets since major simplification of synthetic sequences are expected from this approach. Pushing C–H amination to its limits has led to a deeper understanding of the reaction mechanism and scope. In this review, we present a description of the specific challenges facing catalytic C–H amination in the synthesis of natural products and related compounds, as well as innovative tactics created to overcome them. By identifying and discussing the major insights gained and strategies designed, we hope that this review will stimulate further progress in C–H amination chemistry and beyond.

中文翻译：

催化CHH胺化的极限：挑战和解决方案

催化的C–H胺化反应可将未活化的C（sp ³）–H键具有高水平的区域，化学和立体选择性。作为释放惰性C–H键潜力的有力工具，C–H胺化化学已被用于制备具有挑战性的合成目标，因为这种方法有望大大简化合成序列。将C–H胺化推至极限已导致人们对反应机理和范围有了更深入的了解。在这篇综述中，我们介绍了在天然产物和相关化合物的合成中催化CHH胺化所面临的具体挑战，以及为克服这些挑战而提出的创新策略。我们希望通过鉴定和讨论所获得的主要见解和设计的策略，希望本次审查能刺激C–H胺化化学及其他方面的进一步发展。

更新日期：2017-09-12

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