Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes,Organic Chemistry Frontiers

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Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-04 00:00:00 , DOI: 10.1039/c7qo00611j
Hongtai Chen _{1,

2,

3,

4,

5} , Xiaoyang Wang _{1,

2,

3,

4,

5} , Minjie Guo _{3,

4,

5,

6,

7} , Wentao Zhao _{1,

2,

3,

4,

5} , Xiangyang Tang _{1,

2,

3,

4,

5} , Guangwei Wang _{1,

2,

3,

4,

5}

Affiliation

A novel method for the synthesis of α,α-difluoro-γ-lactam derivatives has been developed using a copper/amine catalyst via a tandem radical cyclization pathway. This protocol provides a convenient and straightforward strategy for the rapid construction of various 3,3-difluoro-γ-lactam moieties from easily available alkenes and N-aryl bromodifluoroacetamide as starting materials under mild reaction conditions.

中文翻译：

通过烯烃的氨基二氟烷基化高效高效地合成α，α-二氟-γ-内酰胺

已经通过串联自由基环化途径使用铜/胺催化剂开发了一种合成α，α-二氟-γ-内酰胺衍生物的新方法。该方案为在温和的反应条件下，从容易获得的烯烃和N-芳基溴二氟乙酰胺为起始原料快速构建各种3,3-二氟-γ-内酰胺部分提供了方便而直接的策略。

更新日期：2017-09-12

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