Multiplex coaxial flow focusing for producing multicompartment Janus microcapsules with tunable material compositions and structural characteristics,Lab on a Chip

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Multiplex coaxial flow focusing for producing multicompartment Janus microcapsules with tunable material compositions and structural characteristics
Lab on a Chip ( IF 6.1 ) Pub Date : 2017-08-09 00:00:00 , DOI: 10.1039/c7lc00769h
Qiang Wu _{1,

2,

3,

4} , Chaoyu Yang _{1,

2,

3,

4} , Guangli Liu _{1,

2,

3,

4} , Wanghuai Xu _{1,

2,

3,

4} , Zhiqiang Zhu _{1,

2,

3,

4} , Ting Si _{2,

3,

4,

5} , Ronald X. Xu _{1,

2,

3,

4,

6}

Affiliation

We propose a simple but efficient multiplex coaxial flow focusing (MCFF) process for single-step fabrication of multicompartment Janus microcapsules (MJMs) in a wide range of operating parameters. The produced MJMs consist of a multicompartmental core–shell structure with material compositions tunable in individual shell and core compartments. Potential applications of such a MJM agent are demonstrated in both benchtop and in vitro experiments. For the benchtop experiment, magnetic nanoparticles are loaded into one of the shell compartments and photopolymerized under ultraviolet light for controlled alignment and rotation of the microcapsules in a magnetic field. For the in vitro experiment, four different types of cells are encapsulated in the desired compartments of sodium alginate MJMs and co-cultured for seven days. By increasing the number of coaxial needles, we are also able to produce MJMs with three or more compartments. Our studies have shown that the proposed MCFF process is able to produce MJMs with desired material compositions and narrow size distribution. This process is inexpensive and scalable for mass production of various MJMs in its potential applications in biomedical imaging, drug delivery, and regenerative medicine.

中文翻译：

多重同轴流聚焦用于生产具有可调材料组成和结构特征的多室Janus微胶囊

我们提出了一种简单而有效的多重同轴流聚焦（MCFF）工艺，用于在广泛的操作参数范围内单步制造多室Janus微胶囊（MJMs）。所生产的MJM由多隔室的核壳结构组成，其材料成分可在各个壳室和核室中进行调整。这种MJM试剂的潜在应用已在台式和体外实验中得到证实。对于台式实验，将磁性纳米颗粒加载到其中一个壳室中，并在紫外光下进行光聚合，以控制微胶囊在磁场中的排列和旋转。对于体外实验中，将四种不同类型的细胞封装在藻酸钠MJM的所需隔室中，并共培养7天。通过增加同轴针的数量，我们还能够生产具有三个或更多隔室的MJM。我们的研究表明，提出的MCFF工艺能够生产出具有所需材料成分和窄尺寸分布的MJM。该方法在生物医学成像，药物输送和再生医学的潜在应用中，便宜且可扩展以大规模生产各种MJM。

更新日期：2017-09-12

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