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Morphology-Controlled Synthesis of Lignin Nanocarriers for Drug Delivery and Carbon Materials
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00278 Doungporn Yiamsawas 1 , Sebastian J. Beckers 1 , Hao Lu 1 , Katharina Landfester 1 , Frederik R. Wurm 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00278 Doungporn Yiamsawas 1 , Sebastian J. Beckers 1 , Hao Lu 1 , Katharina Landfester 1 , Frederik R. Wurm 1
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Lignin is an abundant biopolymer that is mainly burned for energy production today. However, using it as a polyfunctional macromolecular building block would be desirable. Herein, Kraft lignin was modified through esterification of its hydroxyl groups with methacrylic anhydride. Then lignin nanocarriers with different morphologies (solid nanoparticles, core–shell structures, porous nanoparticles) were produced by a combination of miniemulsion polymerization and a solvent evaporation process. A UV-active cargo is used as a drug model to investigate the release behavior of the lignin nanocarriers depending on their morphology. To prove the enzymatic response of the lignin nanocarriers, we tested the enzyme laccase as a trigger to release the encapsulated cargo. Furthermore, porous lignin nanoparticles with high surface area were produced by carbonization. The carbon material has a high potential as an adsorbent, which was studied by adsorption tests with methylene blue. These biodegradable nanocarriers based on the polyfunctional bioresource lignin may find useful application as novel drug delivery vehicle in agriculture or as carbon materials for water purification.
中文翻译：
形态控制合成木质素纳米载体的药物传递和碳材料
木质素是一种丰富的生物聚合物，如今主要用于能源生产而燃烧。然而，将其用作多官能大分子结构单元将是期望的。此处，硫酸盐木质素通过其羟基与甲基丙烯酸酐的酯化改性。然后，通过细乳液聚合和溶剂蒸发工艺的组合，生产出具有不同形态（固体纳米颗粒，核-壳结构，多孔纳米颗粒）的木质素纳米载体。使用具有紫外线活性的货物作为药物模型来研究木质素纳米载体的释放行为，具体取决于它们的形态。为了证明木质素纳米载体的酶促反应，我们测试了酶漆酶作为释放包封货物的触发因素。此外，通过碳化制备具有高表面积的多孔木质素纳米颗粒。碳材料具有高吸附潜力，已通过亚甲基蓝的吸附测试进行了研究。这些基于多官能生物资源木质素的可生物降解的纳米载体可以作为农业中的新型药物递送载体或用于水净化的碳材料有用的应用。
更新日期：2017-09-12
中文翻译：
形态控制合成木质素纳米载体的药物传递和碳材料
木质素是一种丰富的生物聚合物，如今主要用于能源生产而燃烧。然而，将其用作多官能大分子结构单元将是期望的。此处，硫酸盐木质素通过其羟基与甲基丙烯酸酐的酯化改性。然后，通过细乳液聚合和溶剂蒸发工艺的组合，生产出具有不同形态（固体纳米颗粒，核-壳结构，多孔纳米颗粒）的木质素纳米载体。使用具有紫外线活性的货物作为药物模型来研究木质素纳米载体的释放行为，具体取决于它们的形态。为了证明木质素纳米载体的酶促反应，我们测试了酶漆酶作为释放包封货物的触发因素。此外，通过碳化制备具有高表面积的多孔木质素纳米颗粒。碳材料具有高吸附潜力，已通过亚甲基蓝的吸附测试进行了研究。这些基于多官能生物资源木质素的可生物降解的纳米载体可以作为农业中的新型药物递送载体或用于水净化的碳材料有用的应用。
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