Asthma is a chronic respiratory condition frequently associated with aberrant airway and systemic inflammation. Various inflammatory phenotypes in asthmatic airways have been described that relate to clinical phenotypes and impact on responses to conventional and novel asthma therapies. Macrophages are abundant immunocytes in the lung, capable of mounting diverse responses required for homeostasis and defence against pathogens. Here, we summarise the clinical evidence regarding macrophage dysfunction in asthma. We also describe evidence supporting the role of macrophages as therapeutic targets in asthma. We conclude that macrophage dysfunction in asthma is highly prevalent and heterogeneous, and hypothesise that macrophages may play roles in promoting the discrete inflammatory phenotypes of asthma. These clinical findings, along with recent ground-breaking insights into the ontogeny, behavioural complexity and longevity of pulmonary macrophages, support continued research into the role of macrophages as disease modifiers, biomarkers and therapeutic targets in asthma. Lung macrophages display numerous, therapeutically targetable, context-specific dysfunctions in asthma http://ow.ly/g14430cQhp4

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巨噬细胞功能障碍在哮喘发病机制和治疗中的作用

哮喘是一种慢性呼吸系统疾病，通常与气道异常和全身炎症有关。已经描述了哮喘气道中的各种炎症表型，它们与临床表型和对常规和新型哮喘疗法的反应的影响有关。巨噬细胞是肺中丰富的免疫细胞，能够产生体内平衡和防御病原体所需的多种反应。在这里，我们总结了有关哮喘巨噬细胞功能障碍的临床证据。我们还描述了支持巨噬细胞作为哮喘治疗靶点作用的证据。我们得出结论，哮喘中的巨噬细胞功能障碍是高度普遍和异质的，并且假设巨噬细胞可能在促进哮喘的离散炎症表型中发挥作用。这些临床发现，连同最近对肺巨噬细胞个体发育、行为复杂性和寿命的突破性见解，支持对巨噬细胞作为哮喘疾病调节剂、生物标志物和治疗靶点作用的持续研究。肺巨噬细胞在哮喘中表现出许多可治疗靶向的特定环境功能障碍 http://ow.ly/g14430cQhp4