Whether obesity is a cause of type 2 diabetes mellitus and coronary heart disease or a shared risk factor has been an enduring subject of debate. Lyall and colleagues have used Mendelian randomization to conclude that there is a causal relationship between obesity and cardiometabolic disease. However, the analyses fail key inherent assumptions. The article does not negate a large body of data indicating that insulin resistance is the primary mechanism driving the progression of cardiometabolic disease.

中文翻译：

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肥胖：肥胖和心脏代谢疾病-比目光更远

肥胖是引起2型糖尿病和冠心病的原因还是共同的危险因素一直是争论不休的话题。Lyall及其同事使用孟德尔随机法得出结论，认为肥胖与心脏代谢疾病之间存在因果关系。但是，这些分析未能通过关键的固有假设。这篇文章并没有否定大量数据，这些数据表明胰岛素抵抗是驱动心脏代谢疾病进展的主要机制。