The consolidation of context-dependent emotional memory requires communication between the hippocampus and the basolateral amygdala (BLA), but the mechanisms of this process are unknown. We recorded neuronal ensembles in the hippocampus and BLA while rats learned the location of an aversive air puff on a linear track, as well as during sleep before and after training. We found coordinated reactivations between the hippocampus and the BLA during non-REM sleep following training. These reactivations peaked during hippocampal sharp wave-ripples (SPW-Rs) and involved a subgroup of BLA cells positively modulated during hippocampal SPW-Rs. Notably, reactivation was stronger for the hippocampus-BLA correlation patterns representing the run direction that involved the air puff than for the 'safe' direction. These findings suggest that consolidation of contextual emotional memory occurs during ripple-reactivation of hippocampus-amygdala circuits.

中文翻译：

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睡眠期间海马-杏仁体系统中情绪记忆的重新激活。

依赖于情境的情感记忆的巩固要求海马体与基底外侧杏仁核（BLA）之间进行交流，但是该过程的机制尚不清楚。我们记录了海马和BLA中的神经元合奏，而大鼠则在线性轨道上以及训练前后的睡眠中了解到了厌恶性气团的位置。我们发现训练后非快速眼动睡眠期间海马和BLA之间的协同激活。这些再激活在海马尖波波纹（SPW-Rs）期间达到峰值，并涉及在海马SPW-Rs期间受到正调控的BLA细胞亚群。值得注意的是，代表涉及气喘的运行方向的海马-BLA相关模式的重新激活要比“安全”方向的激活更强。