The negative impacts of residual antibiotics in the environment on ecosystem and human health are big concerns. However, little information is available on the antibiotic bioaccumulation in aquaculture farms. In this study, the bioaccumulative potentials of 21 antibiotics in the plasma, bile, liver and muscle of cultured fish from a typical aquaculture area were systematically investigated.

Results

indicated that antibiotic distribution in the cultured fish was mainly influenced by species and specific substances. The mean values of log bioaccumulation factors (Log BAFs) for the detected antibiotics were in the range of 0.43-3.70, 0.36-4.75, −0.31-4.48, and 0.23-4.33 in the fish plasma, bile, liver and muscle tissues, respectively. For grass carp, both ciprofloxacin and enrofloxacin showed high transportability from the plasma to the muscle and liver. The correlations of various antibiotic concentrations between the plasma and the other three tissues indicated that the concentrations of ciprofloxacin and enrofloxacin in the fish tissues could be predicted by their concentrations in the plasma. Based on the calculated hazard quotients, human health risk evaluation of antibiotic exposure by fish consumption indicated that the consumption of these cultured fish posed low risks to human health.

中文翻译：

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典型水产养殖区养殖鱼类的组织分布，生物蓄积特性和健康风险

环境中残留抗生素对生态系统和人类健康的负面影响是人们关注的重大问题。但是，关于水产养殖场中抗生素生物积累的信息很少。在这项研究中，系统地研究了来自典型水产养殖区的养殖鱼类的血浆，胆汁，肝脏和肌肉中21种抗生素的生物蓄积潜力。

结果

研究表明，养殖鱼类中的抗生素分布主要受物种和特定物质的影响。在鱼的血浆，胆汁，肝脏和肌肉组织中，所检测到的抗生素的对数生物富集因子（Log BAF）的平均值分别在0.43-3.70、0.36-4.75，-0.31-4.48和0.23-4.33的范围内。对于草鱼，环丙沙星和恩诺沙星均显示出从血浆到肌肉和肝脏的高运输性。血浆和其他三个组织之间各种抗生素浓度的相关性表明，鱼组织中环丙沙星和恩诺沙星的浓度可以通过血浆中的浓度来预测。根据计算出的危险商，