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Bioaccumulation Behavior of Pharmaceuticals and Personal Care Products in Adult Zebrafish (Danio rerio): Influence of Physical-Chemical Properties and Biotransformation
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2017-09-11 00:00:00 , DOI: 10.1021/acs.est.7b02918 Fangfang Chen 1 , Zhiyuan Gong 1, 2 , Barry C. Kelly 3
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2017-09-11 00:00:00 , DOI: 10.1021/acs.est.7b02918 Fangfang Chen 1 , Zhiyuan Gong 1, 2 , Barry C. Kelly 3
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The factors influencing bioaccumulation of pharmaceuticals and personal care products (PPCPs) in aquatic organisms are not well understood. The present study involved a comprehensive laboratory investigation to assess the bioaccumulation behavior of several PPCPs in adult zebrafish (Danio rerio). The studied PPCPs included several ionogenic organic compounds (IOCs) such as weak acids and weak bases. Experiments involved two exposure groups (high and low) and a control group, with a 6 day aqueous exposure, followed by a 7 day depuration phase under flow-through conditions. Uptake rate constants (ku) ranged between 0.19 and 8610 L·kg–1·d–1, while depuration rate constants (kd) ranged between 0.14 and 5.14 d–1 in different fish tissues. Steady-state bioconcentration factor (BCFss) values varied widely among the studied PPCPs, ranging from 0.09 to 6,460. In many cases, BCFss values of individual PPCPs differed substantially among different fish tissues. Positive linear relationships were observed between log BCFss values and physical-chemical properties such as octanol–water distribution coefficients (log Dow), membrane–water distribution coefficients (log Dmw), albumin–water distribution coefficients (log DBSAw), and muscle protein–water distribution coefficients (log Dmpw), indicating the importance of lipid–, phospholipid–, and protein–water partitioning. The results also showed that for many PPCPs, the estimated whole-body metabolism rate constant (km) values were comparable to the observed depuration rate (kd), indicating that metabolism plays a major role in the overall elimination of these compounds in zebrafish. An exception was sertraline, which exhibited a kd value (0.4–0.5 d–1) that was much higher than the estimated whole-body km (0.03 d–1). Overall, the results help to better understand the influence of physical-chemical properties and biotransformation on bioaccumulation behavior of these contaminants of concern in aquatic organisms.
中文翻译：
成年斑马鱼（Danio rerio）中药物和个人护理产品的生物蓄积行为：物理化学性质和生物转化的影响
影响药物和个人护理产品（PPCP）在水生生物体内生物富集的因素尚不十分清楚。本研究涉及全面的实验室调查，以评估成年斑马鱼（Danio rerio）中几种PPCP的生物蓄积行为。所研究的PPCP包括几种离子型有机化合物（IOC），例如弱酸和弱碱。实验涉及两个暴露组（高和低）和对照组，分别在水中暴露6天，然后在流通条件下进行7天净化阶段。吸收速率常数（ķ û）介于0.19之间和8610 L·千克-1 ·d -1，而净化率常数（ķ d）在不同鱼类组织中的范围在0.14至5.14 d –1之间。在研究的PPCP中，稳态生物富集因子（BCF ss）值差异很大，范围从0.09到6,460。在许多情况下，不同鱼类组织中各个PPCP的BCF ss值存在很大差异。在log BCF ss值与物理化学性质之间观察到正线性关系，例如辛醇-水分配系数（log D ow），膜-水分配系数（log D mw），白蛋白-水分配系数（log D BSAw），和肌肉蛋白质-水的分配系数（log Dmpw），表明脂类，磷脂和蛋白质-水分配的重要性。结果还表明，对于许多PPCP，估计的全身代谢速率常数（k m）值可与观察到的净化率（k d）相媲美，这表明代谢在斑马鱼中这些化合物的整体清除中起主要作用。舍曲林例外，其k d值（0.4–0.5 d –1）比估计的全身k m（0.03 d –1）高得多。）。总体而言，这些结果有助于更好地了解理化性质和生物转化对这些在水生生物中关注的污染物的生物累积行为的影响。
更新日期：2017-09-11
中文翻译：
成年斑马鱼（Danio rerio）中药物和个人护理产品的生物蓄积行为：物理化学性质和生物转化的影响
影响药物和个人护理产品（PPCP）在水生生物体内生物富集的因素尚不十分清楚。本研究涉及全面的实验室调查，以评估成年斑马鱼（Danio rerio）中几种PPCP的生物蓄积行为。所研究的PPCP包括几种离子型有机化合物（IOC），例如弱酸和弱碱。实验涉及两个暴露组（高和低）和对照组，分别在水中暴露6天，然后在流通条件下进行7天净化阶段。吸收速率常数（ķ û）介于0.19之间和8610 L·千克-1 ·d -1，而净化率常数（ķ d）在不同鱼类组织中的范围在0.14至5.14 d –1之间。在研究的PPCP中，稳态生物富集因子（BCF ss）值差异很大，范围从0.09到6,460。在许多情况下，不同鱼类组织中各个PPCP的BCF ss值存在很大差异。在log BCF ss值与物理化学性质之间观察到正线性关系，例如辛醇-水分配系数（log D ow），膜-水分配系数（log D mw），白蛋白-水分配系数（log D BSAw），和肌肉蛋白质-水的分配系数（log Dmpw），表明脂类，磷脂和蛋白质-水分配的重要性。结果还表明，对于许多PPCP，估计的全身代谢速率常数（k m）值可与观察到的净化率（k d）相媲美，这表明代谢在斑马鱼中这些化合物的整体清除中起主要作用。舍曲林例外，其k d值（0.4–0.5 d –1）比估计的全身k m（0.03 d –1）高得多。）。总体而言，这些结果有助于更好地了解理化性质和生物转化对这些在水生生物中关注的污染物的生物累积行为的影响。
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