We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au–Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.

中文翻译：

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耐氯化物的金（I）催化炔烃的区域选择性氢氯化反应

我们已经开发了一种高度区域选择性的均相金（I）在室温下催化未活化炔烃的抗氢氯化反应。通过使用Au-Cl键的氢键活化作用，我们克服了常规阳离子金催化剂与氯化物之间的不相容性。这种方法是可扩展的，具有出色的官能团耐受性，并且可以在露天进行。