Catalytic Efficient Nazarov Reaction of Unactivated Aryl Vinyl Ketones via a Bidentate Diiron Lewis Acid Activation Strategy,Advanced Synthesis & Catalysis

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Catalytic Efficient Nazarov Reaction of Unactivated Aryl Vinyl Ketones via a Bidentate Diiron Lewis Acid Activation Strategy
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-11 10:18:17 , DOI: 10.1002/adsc.201700820
Xin Zhou ₁ , Yukun Zhao ₁ , Yang Cao ₁ , Lirong He ₁

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A catalytic highly efficient Nazarov reaction of unactivated aryl vinyl ketones has been accomplished by employing aryl boric acid/Fe(OTf)₃. Significant progress was obtained in utilizing an extremely broad substrate scope, giving indanones in high yields with high regioselectivities and diastereoselectivities. The mechanistic investigation supports a bidentate diiron Lewis acid catalysis, and the strong double electrophilic activation of aryl vinyl ketones via simultaneous coordination plays a key role in achieving a high reaction efficiency.

中文翻译：

通过双齿二铁刘易斯酸活化策略催化未活化的芳基乙烯基酮的纳扎罗夫催化高效反应

通过使用芳基硼酸/ Fe（OTf）₃可以完成未活化的芳基乙烯基酮的高效催化Nazarov反应。在利用极其广泛的底物范围方面获得了重大进展，从而以高产率获得了茚满酮，并具有较高的区域选择性和非对映选择性。机理研究支持双齿二铁路易斯酸的催化，芳基乙烯基酮通过同时配位的强双亲电活化在实现高反应效率方面起着关键作用。

更新日期：2017-09-11

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