A Cooperative Ternary Catalysis System for Asymmetric Lactonizations of α-Ketoesters,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Cooperative Ternary Catalysis System for Asymmetric Lactonizations of α-Ketoesters
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-11 10:17:59 , DOI: 10.1002/adsc.201701015
Kathleen J. R. Murauski ₁ , Daniel M. Walden ₂ , Paul Ha-Yeon Cheong ₂ , Karl A. Scheidt ₁

Affiliation

A general and enantioselective N-heterocyclic carbene (NHC)-catalyzed lactonization of simple enals and α-ketoesters has been discovered using a new ternary cooperative catalytic system. The highly selective annulation was achieved by using a combination of a chiral NHC, a hydrogen-bond donor, and a metal salt, facilitating self-assembly of the reactive partners. A proposed model for this new mode of NHC chiral relay catalysis is supported by experimental and computational mechanistic studies.

中文翻译：

α-酮酸酯不对称渗碳的三元协同催化系统

使用新的三元协同催化体系，发现了一种简单的对映体和α-酮酸酯的一般和对映选择性的N-杂环卡宾（NHC）催化的内酯化反应。通过使用手性NHC，氢键供体和金属盐的组合来实现高度选择性的环化反应，这有助于反应性伙伴的自组装。实验和计算机制研究为这种新型的NHC手性中继催化模式提供了一个建议的模型。

更新日期：2017-09-11

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11