Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide,European Journal of Organic Chemistry

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Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-11 10:22:28 , DOI: 10.1002/ejoc.201701030
Stephen J. Chawner ₁ , Manuel J. Cases-Thomas ₂ , James A. Bull ₁

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A divergent synthesis of varied cyclopropane-containing compounds has been developed by utilizing a single central bifunctional scaffold. Products were designed to possess desirable physicochemical properties and 3-dimensional structure for use as lead-like compounds, fragments and building blocks within drug discovery.

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