当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-11 10:22:28 , DOI: 10.1002/ejoc.201701030
Stephen J. Chawner 1 , Manuel J. Cases-Thomas 2 , James A. Bull 1
Affiliation  

A divergent synthesis of varied cyclopropane-containing compounds has been developed by utilizing a single central bifunctional scaffold. Products were designed to possess desirable physicochemical properties and 3-dimensional structure for use as lead-like compounds, fragments and building blocks within drug discovery.

中文翻译:

通过钴催化的苯基乙烯基硫醚的环丙烷丙烷化合成含环丙烷的铅样化合物,片段和结构单元

通过使用单一的中心双功能支架,已开发出各种含环丙烷化合物的多样化合成方法。产品被设计为具有理想的理化特性和3维结构,可用作药物发现中的铅样化合物,片段和结构单元。
更新日期:2017-09-11
down
wechat
bug