How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.

中文翻译：

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烟气诱导的表观基因组变化为致癌突变提供了肥沃的土壤。

遗传和表观遗传事件如何协同产生致癌状态尚不清楚。在本期《癌细胞》中，Vaz等人。提供了令人信服的证据，证明长期吸烟会导致进行性表观遗传学改变，这是引发肺癌的关键遗传事件的主要诱因。