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When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.
Cancer Cell ( IF 48.8 ) Pub Date : 2017-09-11 , DOI: 10.1016/j.ccell.2017.08.014
Zhihui Liu 1 , Carol J Thiele 1
Affiliation  

LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.

中文翻译:


当 LMO1 遇到 MYCN 时,神经母细胞瘤就会发生转移。



LMO1是一种高危神经母细胞瘤易感基因,但LMO1如何与MYCN协同参与神经母细胞瘤的肿瘤发生尚不清楚。在本期《癌细胞》中,Zhu 等人。开发一种新型斑马鱼模型,阐明 LMO1 和 MYCN 协同引发神经母细胞瘤并促进转移性疾病进展的机制。
更新日期:2017-09-11
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