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Transplantation: IdeS to desensitize organ allograft recipients
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2017-09-11 00:00:00 , DOI: 10.1038/nrneph.2017.128 Georg A. Böhmig , Lionel Rostaing
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2017-09-11 00:00:00 , DOI: 10.1038/nrneph.2017.128 Georg A. Böhmig , Lionel Rostaing
Transplantation: IdeS to desensitize organ allograft recipients
中文翻译:
移植:Ides使异体器官受体脱敏
移植:Ides使异体器官受体脱敏
更新日期:2017-09-12
Nature Reviews Nephrology, Published online: 11 September 2017; doi:10.1038/nrneph.2017.128
HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.
中文翻译:
移植:Ides使异体器官受体脱敏
移植:Ides使异体器官受体脱敏
Nature Reviews Nephrology,在线发布:2017年9月11日;doi:10.1038 / nrneph.2017.128
HLA致敏大大增加了移植排斥和失败的风险。源自化脓性链球菌(IdeS)的IgG内肽酶可能是脱敏的一种有吸引力的新疗法。最近的数据表明,Ides能有效消耗抗HLA IgG,为致敏受体成功进行肾移植创造了治疗窗口。