Transplantation: IdeS to desensitize organ allograft recipients

Nature Reviews Nephrology, Published online: 11 September 2017; doi:10.1038/nrneph.2017.128

HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

中文翻译：

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移植：Ides使异体器官受体脱敏

移植：Ides使异体器官受体脱敏

Nature Reviews Nephrology，在线发布：2017年9月11日；doi：10.1038 / nrneph.2017.128

HLA致敏大大增加了移植排斥和失败的风险。源自化脓性链球菌（IdeS）的IgG内肽酶可能是脱敏的一种有吸引力的新疗法。最近的数据表明，Ides能有效消耗抗HLA IgG，为致敏受体成功进行肾移植创造了治疗窗口。