Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones,Organic Chemistry Frontiers

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Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-04 00:00:00 , DOI: 10.1039/c7qo00677b
Xueke Liu _{1,

2,

3,

4,

5} , Ping Qian _{1,

2,

3,

4,

5} , Yi Wang _{1,

2,

3,

4,

5} , Yi Pan _{1,

2,

3,

4,

5}

Affiliation

A convenient metal-free sequential decarbonylative annulation of unactivated alkenes for the construction of quinazolinones and dihydroisoquinolinones has been developed. This strategy features the oxidative decarbonylation of various secondary and tertiary alkyl aldehydes with N-cyanamide alkenes for the cascade construction of C–C/C–N bonds.

中文翻译：

N-氰胺的无金属顺序脱羰环化反应，用于构建2,3-二氢吡咯并[2,1- b ]喹唑啉-9（1 H）-ones

已经开发了一种方便的，无金属的，未活化的连续的未活化烯烃的环羰基环化反应，用于构造喹唑啉酮和二氢异喹啉酮。该策略的特征是各种仲和叔烷基醛与N-氰酰胺烯烃的氧化脱羰作用，用于C–C / C–N键的级联结构。

更新日期：2017-09-11

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