The lung harbours a diverse array of microbes whose dynamic composition is influenced by both host and environmental factors. Thus far, most studies have described the microbial composition of healthy or diseased lungs and provided an overview of the differences between topographical locations within the respiratory tract. However, insight into the functional mechanisms underlying host−microbe interactions and how they might drive lung health and disease are limited. This review provides an overview of the current mechanistic understanding of the microbiome, crosstalk between tissue compartments, and its involvement in respiratory diseases. Host-microbe interactions are key determinants of early onset and adult lung diseases http://ow.ly/cuDG30dZg19

中文翻译：

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对微生物组在肺部疾病中的功能的机制洞察

肺含有多种微生物，其动态组成受宿主和环境因素的影响。迄今为止，大多数研究都描述了健康或患病肺部的微生物组成，并概述了呼吸道内地形位置之间的差异。然而，对宿主-微生物相互作用的潜在功能机制以及它们如何推动肺部健康和疾病的了解是有限的。本综述概述了目前对微生物组、组织隔室之间的串扰及其与呼吸系统疾病相关的机制理解。宿主-微生物相互作用是早发和成人肺部疾病的关键决定因素 http://ow.ly/cuDG30dZg19