N-Substituted azaindoles have been discovered as pan-PIM kinase inhibitors. Initial SAR, early ADME and PK/PD data of a series of compounds is described and led to the identification of promising pan-PIM inhibitors which validated our interest in the 7-azaindole scaffold and led us to pursue the identification of a clinical candidate.

中文翻译：

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发现N-取代的7-氮杂吲哚作为Pan-PIM激酶抑制剂–铅系列鉴定–第二部分

已经发现N-取代的氮杂吲哚是泛-PIM激酶抑制剂。描述了一系列化合物的初始SAR，早期ADME和PK / PD数据，并导致鉴定出有前途的pan-PIM抑制剂，从而验证了我们对7-氮杂吲哚支架的兴趣，并促使我们进行临床候选物的鉴定。