Gram-scale syntheses of two kinds of bleomycin disaccharides are described. l-gulose subunit 12 was accomplished with a novel and short route in six steps and 37% overall yield from 4, which could be easily prepared from the commercially available inexpensive material d-sorbitol, while 6-deoxy-l-gulose subunit was synthesized in 11 steps in 8% yield from d-glucolactone. The disaccharides were then prepared in a previously reported glycosidation coupling of the 3-O-carbamoyl-mannosyl donor with the l-gulopyranoside acceptors. Both disaccharides were finally obtained in gram-scale and the total synthesis of disaccharide 2 was achieved the first time.

描述了两种博来霉素二糖的克级合成。升-gulose亚基12用在六个步骤，并从37％总产率的新的和短路线完成4，这可能由市售便宜的材料可以容易地制备d -山梨醇，而6-脱氧升-gulose亚基合成分11步完成，d-葡萄糖内酯的收率为8％。然后，在先前报道的3 - O-氨基甲酰基-甘露糖基供体与1-吡喃吡喃糖苷受体的糖苷偶联中制备二糖。最终以克级获得了两种二糖，并且全部合成了二糖2是第一次实现。