OBJECTIVE To assess parent anxiety in response to genetic and islet autoantibody (IA) testing in children at increased genetic risk for type 1 diabetes followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study. RESEARCH DESIGN AND METHODS Parent anxiety about TEDDY children's risk was assessed with the State Anxiety Inventory (SAI). Parents completed the SAI when the child was 3, 6, and 15 months old and annually thereafter. Children were tested for IA every 3 months for 4 years and every 6 months thereafter. Parent SAI scores of 6,799 children followed with IA testing for at least 1 and up to 6 years were examined. RESULTS At study inception, parents showed high levels of anxiety in response to their child's increased genetic type 1 diabetes risk; mothers were more anxious than fathers, and parents with diabetes in the family were more anxious than parents with no family history. In response to repeated IA-negative (IA-) test results, parent anxiety declined to normal levels. Anxiety increased in parents faced with an IA-positive (IA+) test result. Parents faced with two or more types of IA+ test results showed particularly high levels of anxiety (all P < 0.001). CONCLUSIONS Infant genetic screening for type 1 diabetes raises parent anxiety when the child is at increased risk, but anxiety dissipates over time in cases of repeated IA- results. IA+ results heighten parent anxiety, and parents faced with two or more types of IA+ results may experience considerable anxiety for longer periods.

中文翻译：

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我的孩子胰岛自身抗体呈阳性：对父母焦虑的影响。


目的 在青少年糖尿病的环境决定因素 (TEDDY) 研究中，评估自出生起 1 型糖尿病遗传风险增加的儿童父母对遗传和胰岛自身抗体 (IA) 检测的焦虑程度。研究设计和方法 使用状态焦虑量表 (SAI) 评估家长对 TEDDY 儿童风险的焦虑。父母在孩子 3、6 和 15 个月大时完成 SAI，此后每年完成一次。儿童每 3 个月接受一次 IA 检测，持续 4 年，此后每 6 个月进行一次。对 6,799 名儿童的家长 SAI 分数进行了检查，这些儿童接受了至少 1 年至 6 年的 IA 测试。结果 在研究开始时，父母对其孩子遗传性 1 型糖尿病风险增加表现出高度焦虑；母亲比父亲更焦虑，家族中有糖尿病的父母比无家族史的父母更焦虑。针对重复的 IA 阴性 (IA-) 测试结果，家长的焦虑降至正常水平。面对 IA 阳性 (IA+) 测试结果，家长的焦虑感增加。面对两种或两种以上 IA+ 测试结果的家长表现出特别高的焦虑水平（所有 P < 0.001）。结论 当孩子的风险增加时，婴儿 1 型糖尿病基因筛查会增​​加家长的焦虑，但在重复 IA 结果的情况下，焦虑会随着时间的推移而消失。 IA+ 结果会加剧家长的焦虑，而面对两种或多种 IA+ 结果的家长可能会在较长时间内经历相当大的焦虑。