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Targeting and isolation of cancer cells using micro/nanomotors
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2017-09-09 , DOI: 10.1016/j.addr.2017.09.002
Weiwei Gao 1 , Berta Esteban-Fernández de Ávila 1 , Liangfang Zhang 1 , Joseph Wang 1
Affiliation  

Micro/nanomotors distinguish themselves with in situ energy conversion capability for autonomous movement, a feature that confers remarkable potential to improve cancer treatment. In this review article, three areas are highlighted where micro/nanomotors have established themselves with unique contributions, including propelled navigation to promote cancer cell targeting, powered cell membrane penetration to enhance intracellular delivery, and steered isolation of circulating tumor cells for detection. Progress made in these areas has offered promising inspiration and opportunities aimed for enhancing the efficiency and precision of drug targeting to cancer cells, improving the capability of delivering anticancer drug into cytoplasm for bioactivity, and enabling more rapid and sensitive cancer cell detection. Herein, we review each area with highlights of the current and forthcoming micro/nanomotor techniques in advancing cancer diagnosis and treatment.



中文翻译:


使用微/纳米电机靶向和分离癌细胞



微/纳米电机的特点是具有自主运动的原位能量转换能力,这一特性为改善癌症治疗提供了巨大的潜力。在这篇综述文章中,重点介绍了微/纳米电机在三个领域中做出的独特贡献,包括推动导航以促进癌细胞靶向、驱动细胞膜穿透以增强细胞内递送以及引导循环肿瘤细胞的分离以进行检测。这些领域取得的进展为提高药物靶向癌细胞的效率和精度、提高将抗癌药物输送到细胞质中发挥生物活性的能力以及实现更快速和灵敏的癌细胞检测提供了有希望的灵感和机遇。在此,我们回顾了每个领域,重点介绍了当前和即将推出的微/纳米电机技术在推进癌症诊断和治疗方面的进展。

更新日期:2017-09-09
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