In this issue, Catry et al described a study in which inulin-type fructans (ITF) improved endothelial dysfunction in mice.1 They demonstrated that the supplementation of ITF reverses endothelial dysfunction in mesenteric and carotid arteries of apolipoprotein E ( apoE ) gene knockout mice that were fed an n-3 polyunsaturated fatty acid-depleted diet. They further showed that improvement of endothelial dysfunction was accompanied with a change in microbiota composition and key gut peptides. Endothelial dysfunction is a pathological state of the inner lining of the blood vessels which is characterised by a reduction in vasodilation in response to endothelial stimuli and considered an early key marker of cardiovascular disease.2 Impaired synthesis and release of nitric oxide (NO) by the endothelium is considered one of the important mechanisms associated with endothelial dysfunction. A wide variety of risk factors associated with cardiovascular disease have been identified. These include general lifestyle factors such as the typical ‘Western diet’ and smoking, but also disorders, such as metabolic syndrome and type 2 diabetes as well as chronic inflammation. Increasing evidence indicates that the intestinal microbiota plays a key role in the latter risk factors for cardiovascular disease. A recent study demonstrated …

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内皮功能障碍：微生物群的作用是什么？

在本期中，Catry 等人描述了一项研究，其中菊粉型果聚糖 (ITF) 改善了小鼠的内皮功能障碍。1 他们证明补充 ITF 可逆转载脂蛋白 E (apoE) 基因敲除小鼠肠系膜和颈动脉的内皮功能障碍那些被喂食了 n-3 多不饱和脂肪酸的饮食。他们进一步表明，内皮功能障碍的改善伴随着微生物群组成和关键肠道肽的变化。内皮功能障碍是血管内层的病理状态，其特征在于响应内皮刺激的血管舒张减少，被认为是心血管疾病的早期关键标志物。2 内皮细胞合成和释放一氧化氮 (NO) 受损被认为是与内皮功能障碍相关的重要机制之一。已经确定了与心血管疾病相关的多种危险因素。这些因素包括一般的生活方式因素，例如典型的“西方饮食”和吸烟，还包括代谢综合征和 2 型糖尿病以及慢性炎症等疾病。越来越多的证据表明，肠道微生物群在后一种心血管疾病的危险因素中起着关键作用。最近的一项研究表明…… 例如代谢综合征和 2 型糖尿病以及慢性炎症。越来越多的证据表明，肠道微生物群在后一种心血管疾病的危险因素中起着关键作用。最近的一项研究表明…… 例如代谢综合征和 2 型糖尿病以及慢性炎症。越来越多的证据表明，肠道微生物群在后一种心血管疾病的危险因素中起着关键作用。最近的一项研究表明……