We recently read with great interest a review by Adams et al 1 showing that non-alcoholic fatty liver disease (NAFLD) has a profound impact on the onset of extrahepatic diseases, such as cardiovascular diseases and kidney diseases. We fully agree with this conclusion, and the authors have fully elucidated the relationship between NAFLD and extrahepatic diseases. We think that hepatokines produced and secreted by liver may play a critical role in NAFLD-related extrahepatic diseases, which would deepen the understanding of this disease. Fibroblast growth factor 21 (FGF21), a hepatokine that is mainly secreted by the liver, has beneficial effects for improving metabolic …

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肝因子在 NAFLD 相关肝外疾病中的作用：罪魁祸首还是共犯？

我们最近饶有兴趣地阅读了 Adams 等人 1 的评论，该评论显示非酒精性脂肪肝 (NAFLD) 对心血管疾病和肾脏疾病等肝外疾病的发生具有深远的影响。我们完全同意这一结论，作者充分阐明了NAFLD与肝外疾病的关系。我们认为肝脏产生和分泌的肝因子可能在 NAFLD 相关的肝外疾病中起关键作用，这将加深对该病的认识。成纤维细胞生长因子 21 (FGF21) 是一种主要由肝脏分泌的肝因子，具有改善代谢的有益作用……