Objective Functional gastrointestinal disorders (FGIDs) are diagnosed by the presence of a characteristic set of symptoms. However, the current criteria-based diagnostic approach is to some extent subjective and largely derived from observations in English-speaking Western patients. We aimed to identify latent symptom clusters in Asian patients with FGID. Design 1805 consecutive unselected patients with FGID who presented for primary or secondary care to 11 centres across Asia completed a cultural and linguistic adaptation of the Rome III Diagnostic Questionnaire that was translated to the local languages. Principal components factor analysis with varimax rotation was used to identify symptom clusters. Results Nine symptom clusters were identified, consisting of two oesophageal factors (F6: globus, odynophagia and dysphagia; F9: chest pain and heartburn), two gastroduodenal factors (F5: bloating, fullness, belching and flatulence; F8 regurgitation, nausea and vomiting), three bowel factors (F2: abdominal pain and diarrhoea; F3: meal-related bowel symptoms; F7: upper abdominal pain and constipation) and two anorectal factors (F1: anorectal pain and constipation; F4: diarrhoea, urgency and incontinence). Conclusion We found that the broad categorisation used both in clinical practice and in the Rome system, that is, broad anatomical divisions, and certain diagnoses with long historical records, that is, IBS with diarrhoea, and chronic constipation, are still valid in our Asian societies. In addition, we found a bowel symptom cluster with meal trigger and a gas cluster that suggests a different emphasis in our populations. Future studies to compare a non-Asian cohort and to match to putative pathophysiology will help to verify our findings.

中文翻译：

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罗马基金会-亚洲工作组报告：亚洲功能性胃肠病症状群

目的功能性胃肠道疾病 (FGID) 是通过一组特征性症状的存在来诊断的。然而，目前基于标准的诊断方法在某种程度上是主观的，主要来自对讲英语的西方患者的观察。我们旨在确定亚洲 FGID 患者的潜在症状群。设计 1805 名连续未选择的 FGID 患者，他们在亚洲的 11 个中心接受初级或二级护理，完成了罗马 III 诊断问卷的文化和语言改编，并被翻译成当地语言。使用方差极大旋转的主成分因子分析来识别症状簇。结果 确定了九个症状群，包括两个食管因素（F6：球状、吞咽痛和吞咽困难；F9：胸痛和胃灼热），两种胃十二指肠因素（F5：腹胀、饱胀、嗳气和胀气；F8 反流、恶心和呕吐），三种肠道因素（F2：腹痛和腹泻；F3：与膳食相关的肠道症状；F7：上腹痛和便秘）和两种肛门直肠因素（F1：肛门直肠疼痛和便秘；F4：腹泻、尿急和尿失禁）。结论 我们发现临床实践和罗马系统中使用的广泛分类，即广泛的解剖学划分，以及某些具有悠久历史记录的诊断，即伴有腹泻和慢性便秘的 IBS，在我们亚洲人中仍然有效。社会。此外，我们发现了一个带有进餐触发的肠道症状群和一个气体群，表明我们人群的重点不同。