Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.

中文翻译：

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SPOP提示癌症中BET的平衡

散斑型POZ（痘病毒和锌指）蛋白中与癌症相关的突变赋予了新形态活性，改变了其底物亲和力以及对前列腺癌和子宫内膜癌对溴结构域和末端外抑制剂的反应。