The essential job of precision medicine is to match the right drugs to the right patients. In cancer, precision medicine has been nearly synonymous with genomics. However, sobering recent studies have generally shown that most patients with cancer who receive genomic testing do not benefit from a genomic precision medicine strategy. Although some call the entire project of precision cancer medicine into question, I suggest instead that the tools employed must be broadened. Instead of relying exclusively on big data measurements of initial conditions, we should also acquire highly actionable functional information by perturbing-for example, with cancer therapies-viable primary tumor cells from patients with cancer.

中文翻译：

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功能精确的癌症医学-超越了单纯的基因组学。

精密医学的基本工作是将合适的药物与合适的患者相匹配。在癌症中，精密医学几乎是基因组学的代名词。然而，最新的研究令人发人深省，表明接受基因组检测的大多数癌症患者无法从基因组精确医学策略中受益。尽管有人对整个精确癌症医学项目提出了质疑，但我建议必须扩大使用的工具。而不是仅依赖于初始条件的大数据测量，我们还应该通过干扰（例如，使用癌症疗法）来自癌症患者的可行的原发性肿瘤细胞来获得高度可操作的功能信息。