The main aim of this paper is to offer an objective and critical overview of the situation and trends in Analytical Nanoscience and Nanotechnology (AN&N), which is an important break point in the evolution of Analytical Chemistry in the XXI century as they were computers and instruments in the second half of XX century. The first part of this overview is devoted to provide a general approach to AN&N by describing the state of the art of this recent topic, being the importance of it also emphasized. Secondly, particular but very relevant trends in this topic are outlined: the analysis of the nanoworld, the so “third way” in AN&N, the growing importance of bioanalysis, the evaluation of both nanosensors and nanosorbents, the impact of AN&N in bioimaging and in nanotoxicological studies, as well as the crucial importance of reliability of the nanotechnological processes and results for solving real analytical problems in the frame of Social Responsibility (SR) of science and technology. Several reflections are included at the end of this overview written as a bird's eye view, which is not an easy task for experts in AN&N.

本文的主要目的是对分析纳米科学和纳米技术（AN＆N）的状况和趋势进行客观和批判的概述，这是二十一世纪分析化学作为计算机和仪器发展的一个重要突破点。在二十世纪下半叶。本概述的第一部分致力于通过描述此最新主题的技术水平，为AN＆N提供一种通用方法，同时也强调了它的重要性。其次，概述了该主题中特别但非常相关的趋势：纳米世界的分析，AN＆N中的“第三条道路”，生物分析的重要性日益提高，纳米传感器和纳米吸附剂的评估，AN＆N在生物成像和生物成像中的影响。纳米毒理学研究 以及纳米技术过程和结果的可靠性对于解决科学和技术的社会责任（SR）框架中的实际分析问题的至关重要性。本概述的末尾包含了一些鸟瞰图，这对AN＆N专家而言并非易事。