The review is mainly focused on application of thin layer chromatography (TLC) as simple, rapid and inexpensive method for lipophilicity assessment. Among separation techniques, TLC is still one of the most popular for lipophilicity measurement. The principles and methodology of Quantitative Structure Retention Relationship (QSRR) employed to lipophilicity prediction from retention data are presented. Moreover, applications of TLC retention constants in Quantitative Structure Activity Relationship (QSAR) studies were critically overviewed. The paper concerns also bioautography as a TLC method complementary to QSAR studies. In the article, the advantages and limitations of well established and less common planar chromatography modes applied for drug discovery process were discussed.

审查主要侧重于薄层色谱（TLC）的应用，该方法是用于亲脂性评估的简单，快速和廉价的方法。在分离技术中，TLC仍然是亲脂性测量中最受欢迎的技术之一。提出了定量结构保留关系（QSRR）的原理和方法，用于根据保留数据进行亲脂性预测。此外，对TLC保留常数在定量结构活性关系（QSAR）研究中的应用进行了综述。本文还涉及生物自传作为QSAR研究的TLC方法的补充。在本文中，讨论了在药物发现过程中应用完善的和不太常见的平面色谱模式的优缺点。