According to the previously reported potent dual l-peptide PMI of p53-MDM2/MDMX interactions, a series of d-amino acid mutational PMI analogues, PMI-1-4, with enhanced proteolytic resistence and in vitro tumor cell inhibitory activities were reported, of which Liposome-PMI-1 showed a stronger inhibitory activity against the U87 cell lines than Nutlin-3. This d-amino acid mutation strategy may give a hand for enhancing the potential of peptide drugs.

中文翻译：

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d -PMI的氨基酸突变作为p53-MDM2 / MDMX相互作用的有效双肽抑制剂

根据先前报道的有效的双升-肽P53-MDM2 / MDMX相互作用的PMI，一系列d -氨基酸突变PMI类似物，PMI-1 - 4，具有增强的蛋白水解抗性和体外肿瘤细胞抑制活性进行了报道，其中脂质体-PMI-1对U87细胞系的抑制活性强于Nutlin-3。这种d-氨基酸突变策略可以帮助提高肽药物的潜力。