A boron-doped diamond electrode (BDDE) was employed for the first time in the development of a voltammetric method for the simultaneous determination of acetaminophen (ACT), caffeine (CAF) and carisoprodol (CAR). CAR presents a high oxidation potential (2.0 V) and this electrode is suitable for this purpose due to its wide electrochemical potential window. The anodic peak potentials of ACT, CAF and CAR oxidation on the BDDE were found to be 0.980 V, 1.50 V and 2.03 V (vs. Ag/AgCl (3.0 mol L⁻¹ KCl)), respectively, by cyclic voltammetry. After optimization of the analytical conditions employing BDDE at pH 6.0 in a Britton–Robinson buffer solution, square-wave voltammetry (SWV) was applied to the simultaneous determination, by which the peak currents for the three molecules were found to vary linearly with their concentrations in the range of 2.99–283 μmol L⁻¹ for ACT, 2.99–84.8 μmol L⁻¹ for CAF and 19.9–207 μmol L⁻¹ for CAR, with detection limits of 0.768 μmol L⁻¹, 0.771 μmol L⁻¹, and 3.11 μmol L⁻¹, respectively. The proposed method was employed for the simultaneous determination of the three molecules in pharmaceutical formulations and the results were successfully validated with a comparative spectrophotometric method. The use of BDDE showed advantages such as low cost, suitable linearity for simultaneous quantification in real samples, no adsorption problems, and possessing rapidity and excellent reproducibility. This electrode represents a suitable electrochemical sensor for the routine analysis of these drugs.

中文翻译：

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在硼掺杂的金刚石电极上开发carisoprodol的高氧化潜力：一种同时测定对乙酰氨基酚和咖啡因的改进方法

伏安法的开发中首次采用了掺硼金刚石电极（BDDE），用于同时测定对乙酰氨基酚（ACT），咖啡因（CAF）和Carisoprodol（CAR）。CAR具有较高的氧化电势（2.0 V），该电极由于其宽的电化学电势窗口而适合于此目的。ACT，CAF和对BDDE CAR氧化的阳极峰电位被发现是0.980 V，1.50 V和2.03 V（相对于银/氯化银（3.0摩尔大号^-1KCl）），分别通过循环伏安法测定。在Britton-Robinson缓冲溶液中使用pH 6.0的BDDE优化分析条件后，使用方波伏安法（SWV）进行同时测定，结果发现这三个分子的峰值电流随其浓度线性变化在2.99-283微摩尔的范围L ^-1为ACT，2.99-84.8微摩尔大号^-1为CAF和19.9-207微摩尔大号^-1为CAR，具有0.768微摩尔L检测限^-1，0.771微摩尔大号^-1，和3.11μmolL ^-1， 分别。所提出的方法用于同时测定药物制剂中的三种分子，并通过比较分光光度法成功地验证了结果。BDDE的使用显示出以下优点：低成本，在实际样品中同时进行定量时具有合适的线性度，没有吸附问题，并且具有快速性和出色的重现性。该电极代表了用于这些药物的常规分析的合适的电化学传感器。