Rational design of polymeric core shell ratiometric oxygen-sensing nanostructures,Analyst

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Rational design of polymeric core shell ratiometric oxygen-sensing nanostructures
Analyst ( IF 3.6 ) Pub Date : 2017-07-19 00:00:00 , DOI: 10.1039/c7an00753a
Aisling Byrne _{1,

2,

3,

4} , Jaco Jacobs _{1,

2,

3,

4,

5} , Christopher S. Burke _{1,

2,

3,

4} , Aaron Martin _{1,

2,

3,

4} , Andreas Heise _{4,

5,

6,

7} , Tia E. Keyes _{1,

2,

3,

4}

Affiliation

A new approach for the fabrication of luminescent ratiometric sensing nanosensors is described using core–shell nanoparticles in which the probe and reference are spatially separated into the shell and core of the nanostructure respectively. The isolation of the reference in the core of the particle ensures a stable emission reference signal unaffected by the external environment. The core shell structure was prepared by engineering structurally well-defined Ru-conjugated block copolymers which acted as emulsifiers in the miniemulsion polymerisation of BODIPY loaded styrene nanoparticles. The resulting particles are highly stable and show excellent size monodispersity. The nanosensors exhibit dual emission under a single excitation wavelength with a reversible and quantitative ratiometric response to the O₂ content in aqueous media. In the presence of a low concentration of CTAB, the particles cross the cell membrane and the particles show negligible cytotoxicity. Such an approach to sensor nanoparticles should be of value across a range of applications where a stable ratiometric signal in diverse environments is required.

中文翻译：

聚合物核壳比例式氧传感纳米结构的合理设计

描述了一种使用核-壳纳米粒子制造发光比率传感纳米传感器的新方法，其中探针和参比物在空间上分别分为纳米结构的壳和核。粒子核心中参考的隔离确保了稳定的发射参考信号不受外部环境的影响。核壳结构是通过工程设计结构明确的Ru共轭嵌段共聚物制备的，该共聚物在负载BODIPY的苯乙烯纳米粒子的微乳液聚合中充当乳化剂。所得颗粒是高度稳定的，并显示出优异的尺寸单分散性。纳米传感器在单个激发波长下表现出双重发射，对O ₂具有可逆和定量的比例响应在水性介质中的含量。在低浓度的CTAB的存在下，颗粒穿过细胞膜，并且颗粒的细胞毒性可忽略不计。这种用于传感器纳米颗粒的方法在需要在各种环境中保持稳定的比例信号的一系列应用中应该具有价值。

更新日期：2017-09-08

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